Design, Synthesis and Quantitative Structure-Activity Relationship Study of 4]oxazine-7carbonyl)guanidine Derivatives as Potent Na/H Exchange Inhibitors. -A series of racemic as well as optically active (benzoxazine-7carbonyl)guanidine derivatives (VIII) are designed and synthesized starting from 4
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3-Heterocycle-Phenyl N-Alkylcarbamates as FAAH Inhibitors: Design, Synthesis and 3D-QSAR Studies
✍ Scribed by Heikki Käsnänen; Mikko J. Myllymäki; Anna Minkkilä; Antti O. Kataja; Susanna M. Saario; Tapio Nevalainen; Ari M. P. Koskinen; Antti Poso
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 940 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1860-7179
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## Abstract For Abstract see ChemInform Abstract in Full Text.
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## Abstract A facile synthesis of the imidazo[1,5‐__d__]thieno[2,3‐__b__][1,4]thiazine ring system is described. Reaction of 6‐benzyl‐2,3‐dihydro‐1__H__‐thieno[2,3‐__b__][1,4]thiazine‐2‐one (**1**) with potassium __tert__‐butoxide and diethylchlorophosphate gave intermediate **2** which resulted in