3 Glucocorticoid sensitivity and resistance in a human leukaemic lymphoblast cell line
β Scribed by P.A. Bell; C.N. Jones
- Book ID
- 116003456
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- English
- Weight
- 131 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0022-4731
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π SIMILAR VOLUMES
CM-SM is a clonal line of human precursor mononuclear phagocytes inducible to macrophage differentiation in response to the tumor promoter phorbol ester 12-0-tetradecanoyl-phorbol-13-acetate (TPA). Untreated CM-SM cells contain single class, high-affinity (K, = 4.0 x 10' M) glucocorticoid-specific r
The application of glucocorticoids (GC') in human leukemia is based on apoptosis induction but is often hampered by GC resistance. To delineate resistance mechanisms, we examined 5 GC-resistant leukemic cell lines, termed CEM-C7.RI-R5, isolated from the GC-sensitive human acute-1-cell-leukemic line,