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3-dimensional functional imaging of human brain using echo-shifted FLASH MRI

✍ Scribed by Jeff H. Duyn; Venhatha S. Mattay; Roy H. Sexton; Geoffrey S. Sobering; Fernando A. Barrios; Guoying Liu; Joseph A. Frank; Daniel R. Weinberger; Chrit T. W. Moonen

Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 680 KB
Volume: 32
Category: Article
ISSN: 0740-3194
DOI: 10.1002/mrm.1910320123

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A 3‐dimensional MRI method has been developed for functional mapping of the human brain, based on blood oxygenation level dependent (BOLD) contrast mechanisms. The method uses recently introduced principles of echo‐shifted FLASH to acquire a single 3D data set in 20 s. The technique was tested on a conventional 1.5 Tesla clinical scanner with a standard head coil using visual stimulation with a 8 Hz flashing white light, or a varying checkerboard pattern. Areas of increased signal intensity were identified in the visual cortex, consistent with the known functional organization.

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