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3-Amino-2-tetralone Derivatives: Novel Potent and Selective Inhibitors of Aminopeptidase-M (EC-3.4.11.2)

✍ Scribed by C. Schalk; H. Dorchymont; M.F. Jauch; C. Tarnus

Book ID
115564969
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
387 KB
Volume
311
Category
Article
ISSN
0003-9861

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Aminopeptidase N (APN)/CD13 (EC 3.4.11.2) is a transmembrane protease present in a wide variety of human tissues and cell types (endothelial, epithelial, fibroblast, leukocyte). APN/CD13 expression is dysregulated in inflammatory diseases and in cancers (solid and hematologic tumors). APN/CD13 serve