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(2RS,4RS)-2-Hydroxy-4-aminovaleric acid hydrochloride, a structural analogue of GABA

✍ Scribed by Brehm, L. ;Honoré, T.


Book ID
119771367
Publisher
International Union of Crystallography
Year
1978
Weight
292 KB
Volume
34
Category
Article
ISSN
0567-7408

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RS)-2-Amino-2-(3-hydroxy-5-methylisoxazol-4-yl)acetic acid (AMAA) is a potent and selective agonist at the NMDA subgroup of excitatory amino acid receptors. To probe its interaction with these receptors we have developed a synthesis of [3H]AMAA. Bromination of a protected form of AMAA with NBS follo