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290 Pharmacokinetics and tissue biodistribution of a doxorubicin-antibody conjugate in mice

✍ Scribed by P. Sapra; G. Griffiths; S. Govindan; C. Damoci; J. Pickett; A. Sheerin; T. Cardillo; H. Hansen; I. Horak; D. Goldenberg

Book ID
118621473
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
147 KB
Volume
2
Category
Article
ISSN
1359-6349

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✍ M. V. Pimm; M. A. Paul; Y. Ogumuyiwa; R. W. Baldwin 📂 Article 📅 1988 🏛 Springer-Verlag 🌐 English ⚖ 551 KB

The blood kinetics and tissue distribution of a conjugate of daunomycin and a monoclonal antibody (791T/36) have been examined in mice, including nude mice with human tumour xenografts reactive with the antibody. For this the antibody moiety of the conjugate was labelled with 125I and the drug moiet