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2,8-Disubstituted adenosine derivatives as partial agonists for the adenosine A2A receptor

✍ Scribed by Erica W van Tilburg; Matty Gremmen; Jacobien von Frijtag Drabbe Künzel; Miriam de Groote; Ad P IJzerman


Book ID
108479334
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
297 KB
Volume
11
Category
Article
ISSN
0968-0896

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✍ Kenneth A. Jacobson; Lewis K. Pannell; Xiao-Duo Ji; Michael F. Jarvis; Michael W 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 922 KB

The adenosine agonist 2-(4-(2-carboxyethyl)phenylethylamino)-5'-~-ethylcarboxamidoadenosine (CGS21680) was recently reported to be selective for the A, adenosine receptor subtype, which mediates its hypotensive action. To investigate structurelactivity relationships at a distal site, CGS21680 was de