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260 Hepatocellular telomere shortening is a general diagnostic marker and correlates with chromosomal instability of human hepatocellular carcinoma

โœ Scribed by R.R. Plentz; M. Caselitz; J.S. Bleck; M. Gebel; P. Flemming; S. Kubicka; M.P. Manns; K.L. Rudolph


Book ID
117373090
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
79 KB
Volume
40
Category
Article
ISSN
0168-8278

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Telomere shortening correlates with incr
โœ Ruben R. Plentz; Brigitte Schlegelberger; Peer Flemming; Michael Gebel; Hans Kre ๐Ÿ“‚ Article ๐Ÿ“… 2005 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 139 KB

Chromosomal instability (CIN) leads to an increase in aneuploidy and chromosomal aberrations in human hepatocellular carcinoma (HCC). Telomere shortening appears as one mechanism fostering the development of CIN. Whether telomere shortening correlates to specific genetic changes that characterize a