𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Hepatocellular telomere shortening correlates with chromosomal instability and the development of human hepatoma

✍ Scribed by Ruben R. Plentz; Martin Caselitz; Joerg S. Bleck; Michael Gebel; Peer Flemming; Stefan Kubicka; Michael P. Manns; K. Lenhard Rudolph


Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
291 KB
Volume
40
Category
Article
ISSN
0270-9139

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Telomere shortening correlates with incr
✍ Ruben R. Plentz; Brigitte Schlegelberger; Peer Flemming; Michael Gebel; Hans Kre πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 139 KB

Chromosomal instability (CIN) leads to an increase in aneuploidy and chromosomal aberrations in human hepatocellular carcinoma (HCC). Telomere shortening appears as one mechanism fostering the development of CIN. Whether telomere shortening correlates to specific genetic changes that characterize a

Aberrant splicing of the ATM gene associ
✍ Yosuke Ejima; Lichun Yang; Masao S. Sasaki πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 French βš– 181 KB πŸ‘ 2 views

Inherited mutations of the ATM gene are responsible for the human autosomal recessive disorder ataxia-telangiectasia (A-T) characterized by pleiotropic clinical manifestations. ATM mutations are also involved in the development of sporadic human cancers such as T-cell prolymphocytic leukemia and B-c

Increased protein expression of DNA meth
✍ Yoshimasa Saito; Yae Kanai; Tohru Nakagawa; Michiie Sakamoto; Hidetsugu Saito; H πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 French βš– 240 KB

## Abstract Alteration of DNA methylation is one of the most consistent epigenetic changes in human cancers. DNA methyltransferase (DNMT) 1 is a major enzyme involved in establishing genomic methylation patterns. Most of the studies concerning DNMT1 expression in human cancers have been performed o