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257 The impact of microsatellite instability and its correlation with p53 expression in sporadic colorectal cancer (sCRSC)

✍ Scribed by S. Meditskou; V. Kotoula; P. Stravoravdi; A. Barich; G. Geromichalos; Th. Toliou; K. Dimitriadis; K. Papadimitriou

Book ID
118620432
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
166 KB
Volume
1
Category
Article
ISSN
1359-6349

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Defects in mismatch repair (MMR) can result in the development of a 'mutator phenotype', manifest as an increase in DNA replication errors (RERs). Patients with hereditary non-polyposis colorectal cancer (HNPCC) have germline mutations in MMR genes. These patients develop carcinomas of the colon and

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In some tumors, defects in mismatch repair enzymes lead to errors in the replication of simple nucleotide repeat segments RER+ tumors. This condition is commonly known as microsatellite instability (MSI) because of the frequent mutations of microsatellite sequences. Although the MSI phenotype is wel