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2,5-Dimethoxy congeners of (+)- and (-)-3-(3-hydroxyphenyl)-N-n-propylpiperidine

✍ Scribed by Cannon, Joseph G.; Kirschbaum, Karen S.; Amoo, Victor E. D.; Johnson, Alan K.; Long, John Paul

Book ID: 121007838
Publisher: American Chemical Society
Year: 1993
Tongue: English
Weight: 533 KB
Volume: 36
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm00068a021

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## Abstract The motor effects of the partial dopamine agonist (–)‐3‐(3‐hydroxyphenyl)‐N‐n‐propylpiperidine [(–)‐3‐PPP, preclamol] were evaluated in nine patients with Parkinson's disease using a double‐blind, placebocontrolled design. (–)‐3‐PPP monotherapy had an antiparkinsonian effect in five of