✦ LIBER ✦

24p3 in differentiation of myeloid cells

✍ Scribed by Mingli Liu; Marco Prisco; Robert Drakas; David Searles; Renato Baserga

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 367 KB
Volume: 205
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.20400

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✦ Synopsis

24p3 is a secreted lipocalin that has been variously related to apoptosis, proliferation, and the neutrophil lineage of blood cells. We have investigated the expression of 24p3 mRNA and protein in myeloid cell lines induced to differentiate by insulin-like growth factor 1 (IGF-1) and the granulocytic-colony simulating factor (G-CSF). Both these growth factors, which cause myeloid cells to differentiate into granulocytes, induced a marked increase in the expression of both 24p3 protein and mRNA. The mRNA especially appeared early after the cells were induced with either IGF-1 or G-CSF, at a time when the cells were still proliferating and are morphologically undifferentiated. 24p3 can be considered an early marker of granulocytic differentiation.

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