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2,4,6-Trichloropyrimidine. Reaction with sodium amide

✍ Scribed by Thomas J. Delia; Bernard R. Meltsner; Jennifer M. Schomaker

Publisher
Journal of Heterocyclic Chemistry
Year
1999
Tongue
English
Weight
217 KB
Volume
36
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

The first reaction between 2,4,6‐trichloropyrimidine 1 and anionic nitrogen nucleophiles is described. Treatment of 1 with one equivalent of sodium amide gave mixtures of 4‐amino‐2,6‐dichloropyrimidine 2 and 2‐amino‐4,6‐dichloropyrimidine 3. Additional quantities of sodium amide failed to provide either diamino‐ or triaminopyrimidines. Instead, the strongly basic nature of sodium amide led to higher molecular products that were not characterized.

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