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2,4,6-trichloropyrimidine. Reaction with 4-substituted phenolate ions

✍ Scribed by Thomas J. Delia; A. Nagarajan

Publisher
Journal of Heterocyclic Chemistry
Year
1998
Tongue
English
Weight
375 KB
Volume
35
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

A systematic investigation of the reactivity of 2,4,6‐trichloropyrimidine with phenoxide nucleophiles has been conducted. Conditions have been described which lead to mono‐, di‐, and trisubstituted‐pyrimidines. Unexpected product distributions for mono‐ and disubstituted products were observed and explanations for these results are offered.

📜 SIMILAR VOLUMES

2,4,6-trichloropyrimidine. Reaction with
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✍ Jennifer M. Schomaker; Thomas J. Delia 📂 Article 📅 2000 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 485 KB 👁 1 views

## Abstract The reaction of 2,4,6‐trichloropyrimidine 1 with a variety of 4‐substituted anilines 2 has been investigated. Monosubstitution occurs readily for all anilines except those containing strongly electron‐withdrawing groups. The yields of the isomeric products 3 and 4 parallel the Hammet co

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## Abstract The first reaction between 2,4,6‐trichloropyrimidine 1 and anionic nitrogen nucleophiles is described. Treatment of 1 with one equivalent of sodium amide gave mixtures of 4‐amino‐2,6‐dichloropyrimidine 2 and 2‐amino‐4,6‐dichloropyrimidine 3. Additional quantities of sodium amide failed

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Novel synthetic route for 5-substituted
Novel synthetic route for 5-substituted 6-arylmethylluracils from 2,4,6-trichloropyrimidines
✍ Yasser M. Loksha 📂 Article 📅 2009 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 124 KB

## Abstract magnified image Treatment of 2,4,6‐trichloropyrimidines (**1a**, **1b**) with the sodium salt of benzyl cyanide derivatives (**2a**, **2b**) afforded 5‐substituted 4‐aryl(cyanomethyl)‐2,6‐dichloropyrimidines (**3a**, **3b**, **3c**, **3d**, **3e**, **3f**). Compounds **3a**, **3b** were