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2,4,6-Trichlorophenol (TCP) induces chromosome breakage and aneuploidy in vitro

โœ Scribed by Michael J. Armstrong; Sheila M. Galloway; John Ashby


Book ID
113255750
Publisher
Elsevier Science
Year
1993
Weight
592 KB
Volume
303
Category
Article
ISSN
0165-7992

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## Microsatellite instability (MI) and loss of heterozygosity (LOH) were examined in mammary tumors induced in Sprague-Dawley x F344 F1 female rats by 2-amino-l-methyl-6-phenylimidazo[4,5-blpyridine (PhlP). Examination of 62 microsatellite loci revealed M I in nine of 15 (60%) PhlP-induced mammary