2,4-Diaminothieno[2,3-d]pyrimidines as antifolates and antimalarials. 1. Synthesis of 2,4-diamino-5,6,4,8-tetrahydrothianaphtheno[2,3-d]pyrimidines and related compounds
โ Scribed by Rosowsky, A.; Chaykovsky, M.; Chen, K. K. N.; Lin, M.; Modest, E. J.
- Book ID
- 118210227
- Publisher
- American Chemical Society
- Year
- 1973
- Tongue
- English
- Weight
- 504 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0022-2623
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## Abstract magnified image A series of new 2,4โdiaminothieno[2,3โ__d__]โ and 2,4โdiaminopyrrolo[2,3โ__d__]pyrimidine derivatives were synthesised. Reaction of 2โaminoโ4,6โdichloropyrimidineโ5โcarbaldehyde (**1**) with ethyl mercaptoacetate, methyl __N__โmethylglycinate or ethyl glycinate afforded