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2,4-Diaminopyrrolo-[2,3-d]pyrimidines


Book ID
113411139
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
110 KB
Volume
1
Category
Article
ISSN
1359-6446

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πŸ“œ SIMILAR VOLUMES


Synthesis of three carbon atom bridged 2
✍ Aleem Gangjee; Zhengqu Ye; Sherry F. Queener πŸ“‚ Article πŸ“… 2005 πŸ› Journal of Heterocyclic Chemistry 🌐 English βš– 104 KB

A series of seven nonclassical three carbon atom bridged 2,4-diamino-5-substituted-pyrrolo[2,3-d]pyrimidines 1a-g were synthesized as potential inhibitors of dihydrofolate reductase. Selective oxidation of diols 7a-g affords Ξ±-hydroxy ketones 8a-g. Subsequent condensation with malononitrile gave the

Synthesis of 2,4-diaminopyrrolo[2,3-d]py
✍ Gordon L. Bundy; Theresa M. Schwartz; John R. Palmer; Lee S. Banitt; William Wat πŸ“‚ Article πŸ“… 2000 πŸ› Journal of Heterocyclic Chemistry 🌐 English βš– 515 KB

## Abstract The high‐yield synthesis of the 2,4‐diaminopyrrolo[2,3‐__d__] pyrimidine 4 (PNU‐87663) __via__ a Bischler‐like alkylation‐cyclization sequence was reported earlier. We describe herein an alternative synthesis of this potent antioxidant and several analogs based on the thermal Fischer in