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Synthesis of Novel 2,4-Diaminopyrrolo[2,3-d]pyrimidines with Antioxidant, Neuroprotective, and Antiasthma Activity

✍ Scribed by Bundy, Gordon L.; Ayer, Donald E.; Banitt, Lee S.; Belonga, Kenneth L.; Mizsak, Stephen A.; Palmer, John R.; Tustin, James M.; Chin, Jia En; Hall, Edward D.

Book ID
119994493
Publisher
American Chemical Society
Year
1995
Tongue
English
Weight
385 KB
Volume
38
Category
Article
ISSN
0022-2623

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A series of seven nonclassical three carbon atom bridged 2,4-diamino-5-substituted-pyrrolo[2,3-d]pyrimidines 1a-g were synthesized as potential inhibitors of dihydrofolate reductase. Selective oxidation of diols 7a-g affords Ξ±-hydroxy ketones 8a-g. Subsequent condensation with malononitrile gave the