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2′,4′-BNA bearing a 2-pyridine nucleobase for CG base pair recognition in the parallel motif triplex DNA

✍ Scribed by Hari, Yoshiyuki; Matsugu, Sachiko; Inohara, Hiroyasu; Hatanaka, Yuri; Akabane, Masaaki; Imanishi, Takeshi; Obika, Satoshi

Book ID
118218796
Publisher
Royal Society of Chemistry
Year
2010
Tongue
English
Weight
175 KB
Volume
8
Category
Article
ISSN
1477-0520

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Selective recognition of CG interruption
Selective recognition of CG interruption by 2′,4′-BNA having 1-isoquinolone as a nucleobase in a pyrimidine motif triplex formation
✍ Yoshiyuki Hari; Satoshi Obika; Mitsuaki Sekiguchi; Takeshi Imanishi 📂 Article 📅 2003 🏛 Elsevier Science 🌐 French ⚖ 197 KB

To develop a novel nucleoside analogue for the effective recognition of CG interruption in a homopurine -homopyrimidine tract of double-stranded DNA (dsDNA), we succeeded in the synthesis of a triplex-forming oligonucleotide (TFO) containing a novel 2 0 ,4 0 -BNA (Q B ) bearing 1-isoquinolone as a n