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2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and Related Compounds as Antioestrogens: Characterization and Mechanism of Action

โœ Scribed by Safe, S. ;Astroff, B. ;Harris, M. ;Zacharewski, T. ;Dickerson, R. ;Romkes, M. ;Biegel, L.


Book ID
114801701
Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
953 KB
Volume
69
Category
Article
ISSN
0901-9928

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We studied the response t o 2,3,7,8-tetrachlorodibenzo-pdioxin (TCDD) of mouse hepatoma cells that contain a single, integrated copy o f a chimeric gene under the control of a dioxin-responsive DNA domain, which was originally associated with the cytochrome P450/A 7 gene. Our findings indicate that