2,3,7-Trisubstituted Pyrazolo[1,5-d][1,2,4]triazines: Functionally Selective GABAA α3-Subtype Agonists.
✍ Scribed by Robert W. Carling; Michael G. N. Russell; Kevin W. Moore; Andrew Mitchinson; Alexander Guiblin; Alison Smith; Keith A. Wafford; George Marshall; John R. Atack; Leslie J. Street
- Publisher
- John Wiley and Sons
- Year
- 2006
- Weight
- 10 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0931-7597
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## Abstract magnified image __E__‐3‐(__N,N__‐Dimethylamino)‐1‐(3‐methylthiazolo[3,2‐__a__]benzimidazol‐2‐yl)prop‐2‐en‐1‐one (**2**) was synthesized by the reaction of 1‐(3‐methylthiazolo[3,2‐__a__]benzimidazol‐2‐yl)ethanone (**1**) with dimethylformamide‐dimethylacetal. The reaction of **2** with
## Abstract Some novel 3,7‐dimethyl‐6__H__‐pyrazolo[5,1‐c][1,2,4]triazin‐4‐ones were prepared **(3a‐g)**. Compounds **3a,b** were treated with hydrazines to afford various products **7a,b, 8a,b, 9 and lla,b** depending on the type of hydrazine derivative and reaction conditions. The benzoyloxyimino