(±)-2,3,3a,4,5,6-Hexahydro-7-methyl-1,12-dioxo-2,3a-propanophenalene: a new four-ring carbocyclic system
✍ Scribed by Zewge, Daniel ;Thompson, Hugh W. ;Lalancette, Roger A. ;Brunskill, Andrew P. J.
- Publisher
- International Union of Crystallography
- Year
- 2005
- Tongue
- English
- Weight
- 173 KB
- Volume
- 62
- Category
- Article
- ISSN
- 1600-5368
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The 2,3,4,4a,5, isoquinoline-7(7aH)-one ring system is prepared from a 4-arylpyridine precursor by sequential intramolecular enolate addition to a pyridinium ion, Dieckmann cyclization, and catalytic hydrogenation.
Hexahydro-4a-methyl-7,7-diphenyl-1(2H)-naphthalenone. -A clean and efficient route to the hitherto not reported title compound (VIII) starting from the known 3-ethenylcyclohexanone (I) is given. The approach represents a general strategy for the synthesis of related 7,7-diarylhexahydronaphthalenone
In the molecule of the title compound, C 23 H 20 ClFN 2 O 4 , the cyclohexene ring is not planar and has a flattened boat conformation. Intermolecular C-HÁ Á ÁO hydrogen bonds, linking the independent molecules into dimers, may be effective in the stabilization of the crystal structure.