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2′,3′-Didehydro-2′,3′-dideoxy-5-chlorocytidine is a selective anti-retrovirus agent

✍ Scribed by Jan Balzarini; Arthur Van Aerschot; Piet Herdewijn; Erik De Clercq


Book ID
115762018
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
534 KB
Volume
164
Category
Article
ISSN
0006-291X

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## Abstract [5′‐^3^H]‐5‐Chloro‐2′,3′‐diodeoxy‐3′‐fluorouridine (1; R = [^3^H]) was prepared at a specific activity of 10.2 Ci/mmol suitable for development of a radioimmunoassay procedure. The synthetic sequence employed controlled oxidation of unlabelled 1 to the 5′‐aldehyde (2), isolation as the