Antiparkinsonian activity of (+)-PHNO in
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M. Nomoto; S. Stahl; P. Jenner; Dr. C. D. Marsden
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Article
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1987
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John Wiley and Sons
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English
β 542 KB
Administration of MPTP (1-4 mg/kg ip daily for 5-7 days) to common marmosets induced persistent parkinsonian motor deficits. The subcutaneous administration of ( + )-PHNO [( + )-4-propyl-9-hydroxynaphthoxazine; 1-4 ~g / k g ] caused a dose-dependent reversal of the akinesia and incoordination of mov