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209 Monoclonal antibody targeting of the anaplastic lymphoma kinase (ALK) receptor

✍ Scribed by A. Wellstein; J.J. LaConti; S.E. Kim; S. Flachmann; E. Tassi; H. Juhl; A.T. Riegel

Book ID: 119602890
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 43 KB
Volume: 8
Category: Article
ISSN: 1359-6349
DOI: 10.1016/s1359-6349(10)71914-5

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## Abstract The initial identification of the __ALK__ gene, expressed as C‐terminal part of the transforming fusion protein NPM‐ALK in the t(2;5)(p23;q35) lymphoma‐associated chromosomal translocation, revealed a novel receptor tyrosine kinase (RTK). In order to expand the knowledge on __ALK__ expr