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203 Combined cytolytic and noncytolytic intrahepatic CD8 T-lymphocyte reactivity is important for response to antiviral therapy in chronic hepatitis B patients

✍ Scribed by Thjon J. Tang; Jaap Kwekkeboom; Shanta Mancham; Rekha S. Binda; Johannes G. Kusters; Solko W. Schalm; Harry L.A. Janssen


Book ID
119530112
Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
214 KB
Volume
38
Category
Article
ISSN
0270-9139

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Intrahepatic CD8 T-lymphocytes and HBV c
✍ Thjon J. Tang; Robert A. de Man; Johannes G. Kusters; Jaap Kwekkeboom; Wim C.J. 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 170 KB

## Abstract Recognition of HBV‐infected hepatocytes by CD8 T‐lymphocytes is important for viral clearance. Expression of hepatitis B core antigen (HBcAg) in HBV‐infected hepatocytes can trigger this antiviral T‐cell response. The intrahepatic CD8 T‐lymphocytes and HBcAg expression were investigated