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20 Differential regulation of MCP-1 expression in hepatic stellate cells by members of the mitogen-activated protein kinase (MAPK) family

✍ Scribed by Ilaria Petrai; Wanda Delogu; Sabrina Pastacaldi; Andrea Bonacchi; Eva Efsen; Paolo Gentilini; Fabio Marra

Book ID
119631702
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
156 KB
Volume
35
Category
Article
ISSN
1590-8658

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## Abstract ## Objective Mitogen‐activated protein kinases (MAPKs) are activated by proinflammatory stimuli. MAPK phosphatases (MKPs), in particular MKP‐1, have been identified as endogenous negative regulators of MAPK activation. Since MAPKs are known to be important in rheumatoid arthritis (RA)