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Differential regulation of monocyte chemoattractant protein-1 (MCP-1) expression in hepatic stellate cells by members of the mitogen-activated protein kinase (MAPK) family

✍ Scribed by I. Petrai; W. Delogu; S. Pastacaldi; A. Bonacchi; E. Efsen; M. Pinzani; P. Gentilini; F. Marra

Book ID: 117372266
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 163 KB
Volume: 38
Category: Article
ISSN: 0168-8278
DOI: 10.1016/s0168-8278(03)80330-6

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## Abstract ## Objective Mitogen‐activated protein kinases (MAPKs) are activated by proinflammatory stimuli. MAPK phosphatases (MKPs), in particular MKP‐1, have been identified as endogenous negative regulators of MAPK activation. Since MAPKs are known to be important in rheumatoid arthritis (RA)