2-Substituted imidazoles. 3. Metallation of 1-methyl-2-phenyl- and 1-methyl-2-(furyl-2)imidazoles
✍ Scribed by V. M. Stoyanov; M. M. El'chaninov; A. F. Pozharskii
- Publisher
- Springer US
- Year
- 1992
- Tongue
- English
- Weight
- 367 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0009-3122
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l-Methyl-2-nitro-1K-imidazolea carrying d i f f e r e n t 5-side chain. (iaopropyl, hydroxymethylethyl, ethenyl) have been syn- t h e b e d l a b e l l e d with I 4 C a t C2 of t h e imidazole nucleua.
## Abstract New high yield preparation methods were developed for the pharmaceutically interesting compounds, 1‐benzyl‐, 1‐methyl‐, and 1__H__‐5‐[(2‐oxo‐2‐phenyl)ethyl]imidazoles **1a‐c**, respectively. The title compounds were synthesized by four different methods using various starting materials.
We have synthesized 2-(thienyl-2)imidazole and its N-methyl derivative. The latter product was obtained by nitration, bromination, acylation, and formylation, occurring as a rule on the thiophene ring. A general method for methylating 2-R-imidazoles with methyl iodide KOH--dimethoxy ethane is propos