2-Pyridylphosphonates: a new type of modification for nucleotide analogues
β Scribed by Tommy Johansson; Annika Kers; Jacek Stawinski
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- French
- Weight
- 66 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0040-4039
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Suitably protected dithymidine H-phosphonates were quantitatively converted into the corresponding dinucleoside 4-pyridylphosphonates by treatment with 1,8diazabicylo[5.4.0]undec-7-ene (DBU) in the presence of trityl chloride in pyridine. The reaction was found to be stereospecific and proceeded, mo
Diadenosine polyphosphates, discovered over 30 years ago, [1] are ubiquitous components of all cells. Recently, diadenosine triphosphate and tetraphosphate, Ap 3 A and Ap 4 A, have assumed vital significance as ligands for the tumor suppressor protein, Fhit, [2a] which is an Ap 3 A hydrolase [2b] wh