𝔖 Bobbio Scriptorium
✦   LIBER   ✦

2-Polystyrylsulfonyl ethanol supports for the solid-phase syntheses of hydantoins and ureas

✍ Scribed by Wenqiang Huang; Shaoling Cheng; Weimin Sun

Book ID
104230139
Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
56 KB
Volume
42
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

Reaction of sodium polystyrylsulfinate 1 with 2-chloroethanol gave the 2-arylsulfonyl ethanol resin 2, which was converted to the polymer-supported amine 5. Amine 5 was coupled with an isocyanate or an isothiocyanate to give the polymer-supported urea derivatives 6. Treatment of the resin 6 with 6N HCl gave hydantoins 7, while reaction of the same resin with 4N NaOH then HCl gave the urea derivatives 8.

πŸ“œ SIMILAR VOLUMES

Polystyrylsulfonyl chloride resin: an ef
Polystyrylsulfonyl chloride resin: an efficient solid-supported condensation reagent for the solution phase synthesis of esters
✍ N Zander; R Frank πŸ“‚ Article πŸ“… 2001 πŸ› Elsevier Science 🌐 French βš– 89 KB

We describe the use of the readily available polystyryl sulfonyl chloride resin in the solution-phase synthesis of esters from carboxylic acids and alcohols or phenols in high yields and purity. All byproducts can be removed by filtration.

Polystyrylsulfonyl-3-nitro-1H-1,2,4-tria
Polystyrylsulfonyl-3-nitro-1H-1,2,4-triazolide-resin: a new solid-supported reagent for the esterification of amino acids
✍ Norbert Zander; JΓΌrgen Gerhardt; Ronald Frank πŸ“‚ Article πŸ“… 2003 πŸ› Elsevier Science 🌐 French βš– 78 KB

We describe the application of the polystyrylsulfonyl-3-nitro-1H-1,2,4-triazolide-resin, readily available from the corresponding commercially available polystyryl sulfonyl chloride resin, to the solution-phase synthesis of esters from protected a-amino acids and alcohols in high yields and purity w