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2- or 6-(1-azidoalkyl)-5,8-dimethoxy-1,4-naphthoquinone: Synthesis, evaluation of cytotoxic activity; Antitumor activity and inhibitory effect on DNA topoisomerase-I

โœ Scribed by Gyu-Han Chae; Gyu-Yong Song; Yong Kim; Hoon Cho; Dai-Eun Sok; Byung-Zun Ahn


Publisher
Springer
Year
1999
Tongue
English
Weight
665 KB
Volume
22
Category
Article
ISSN
0253-6269

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Naphthazarin derivatives (VIII): Synthes
โœ Yong Kim; Young-Jae You; Byung-Zun Ahn ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 52 KB ๐Ÿ‘ 1 views

6-(1-Acyloxyalkyl)-5,8-dimethoxy-1,4-naphthoquinone (DMNQ; 5,8-dimethoxy-1,4-naphthoquinone) derivatives were synthesized and examined for their inhibitory effect on DNA topoisomerase-I (Topo I) and their antiproliferative activity against L1210 cells. The Topo-I inhibitory effect of 6-(1-hydroxyalk