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Naphthazarin Derivatives (VI): Synthesis, Inhibitory Effect on DNA Topoisomerase-I and Antiproliferative Activity of 2- or 6-(1-Oxyiminoalkyl)-5,8-dimethoxy-1,4-naphthoquinones

โœ Scribed by Gyu-Yong Song; Yong Kim; Young-Jae You; Hoon Cho; Sung-Hoon Kim; Dai-Eun Sok; Byung-Zun Ahn


Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
92 KB
Volume
333
Category
Article
ISSN
0365-6233

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Naphthazarin derivatives (VIII): Synthes
โœ Yong Kim; Young-Jae You; Byung-Zun Ahn ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 52 KB ๐Ÿ‘ 1 views

6-(1-Acyloxyalkyl)-5,8-dimethoxy-1,4-naphthoquinone (DMNQ; 5,8-dimethoxy-1,4-naphthoquinone) derivatives were synthesized and examined for their inhibitory effect on DNA topoisomerase-I (Topo I) and their antiproliferative activity against L1210 cells. The Topo-I inhibitory effect of 6-(1-hydroxyalk