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2′- O ,4′- C -Ethylene-Bridged Nucleic Acid (ENA TM ) for Effective Antisense Formation

✍ Scribed by Morita, Koji; Yamate, Koji; Kurakata, Shin-ichi; Watanabe, Kenji; Imanishi, Takeshi; Koizumi, Makoto

Book ID: 126660543
Publisher: Taylor and Francis Group
Year: 2003
Tongue: English
Weight: 184 KB
Volume: 22
Category: Article
ISSN: 0732-8311
DOI: 10.1081/NCN-120023082

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## Abstract Due to the instability of pyrimidine motif triplex DNA at physiological pH, triplex stabilization at physiological pH is crucial in improving its potential in various triplex‐formation‐based strategies in vivo, such as gene expression regulation, genomic DNA mapping, and gene‐targeted m