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2-Nor-leukotriene analogs: Antagonists of the airway and vascular smooth muscle effects of leukotriene C4, D4 and E4

โœ Scribed by John G. Gleason; Thomas W. Ku; Mary E. McCarthy; Barry M. Weichman; David Holden; Ruth R. Osborn; B. Zabko-Potapovich; Barry Berkowitz; Martin A. Wasserman

Book ID
115757109
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
428 KB
Volume
117
Category
Article
ISSN
0006-291X

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Synthesis of the sulfones of leukotriene
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โœ Yves Girard; Marie Larue; Thomas R. Jones; Joshua Rokach ๐Ÿ“‚ Article ๐Ÿ“… 1982 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 255 KB

A simple one-step preparation of the sulfones of Leukotriene Cq, D, and E, has been developed by the direct oxidation of the parent compounds. An alternative synthesis of these sulfones has also been carried out by reduction of an acetylenic precursor. Slow reacting substance of anaphylaxis (SRS-A)