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2-Methoxyestradiol—Biology and mechanism of action

✍ Scribed by A.O. Mueck; H. Seeger

Book ID: 116892456
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 433 KB
Volume: 75
Category: Article
ISSN: 0039-128X
DOI: 10.1016/j.steroids.2010.02.016

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## Abstract 2‐Methoxyestradiol, a well‐known nonpolar endogenous metabolite of 17β‐estradiol, has been shown to selectively induce apoptosis in a number of cancer cell lines, but not in normal cells. The mechanism of 2‐methoxyestradiol‐induced apoptosis appears to vary considerably in different cel