๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

2-Chloroethyl orthoformate as a reagent for protection in nucleotides synthesis

โœ Scribed by Tsujiaki Hata; Javad Azizian

Publisher
Elsevier Science
Year
1969
Tongue
French
Weight
147 KB
Volume
10
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

โœฆ Synopsis

Acetal derivatives are commonly used in the chemietry of nucleosides and nucleotldes as a protection of alcoholic hydroxyl (1,2,3). The acetals are very stable toward alkalies and anlonoid reagents but are easily hydrolyzed by diluted mineral acid solution at room temperature. For example, treating with mineral acid, purine nucleosides, especially adenosine

๐Ÿ“œ SIMILAR VOLUMES

2-Cyanoacrylates as reagents in heteroat
2-Cyanoacrylates as reagents in heteroatomic synthesis (a review)
โœ Yuri G. Gololobov; Tatiana O. Krylova ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 764 KB

Several types of addition reactions to the C=C bond of alkyI2-cyanoacrylates, CH,=C(CN)COOR (l), are considered. The first examples deal with addition of CH-Acids (pK, less than 13) and of H$ in the presence of catalytic amounts of strong amines, also of mercaptans, thiocarboxylic, and thiophosphori

Nucleotides, Part LXVIII , Acetals as Ne
Nucleotides, Part LXVIII , Acetals as New 2โ€ฒ-O-Protecting Functions for the Synthesis of Oligoribonucleotides: Synthesis of Monomeric Building Units and Oligoribonucleotides
โœ Stefan Matysiak; Wolfgang Pfleiderer ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ German โš– 232 KB ๐Ÿ‘ 2 views

For the efficient synthesis of oligoribonucleotides by the 5'-O-(4,4'-dimethoxytrityl) phosphoramidite approach, the 2'-O-[1-(benzyloxy)ethyl]acetals 56 ยฑ 67 were investigated. Studies with the 2'-O-[1-(benzyloxy)ethyl]-5'-O-(dimethoxytrityl)ribonucleoside 3'-phosphoramidites 56 ยฑ 59 gave, however,