𝔖 Bobbio Scriptorium
✦   LIBER   ✦

2-Chloro N6-methyl-(N)-methanocarba-2′-deoxyadenosine-3′,5′-bisphosphate is a selective high affinity P2Y1 receptor antagonist

✍ Scribed by José L Boyer; Mary Adams; R Gnana Ravi; Kenneth A Jacobson; T Kendall Harden


Book ID
110007259
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
181 KB
Volume
135
Category
Article
ISSN
0007-1188

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


(S)-4-amino-5-chloro-3-iodo-2-methoxy-N-
✍ Tomas de Paulis; Bakula L. Trivedi; Zhang-Jin Zhang; Dennis E. Schmidt; Michael 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 306 KB

TRIZAC is one of the most potent 5-HT-3 receptor antagonist reported to date, having 20-fold higher affinity than (S)-5-iodozacopride. This high affinity (Ki 0.05 +-0.01 nM) and a moderate apparent lipophilicity (log Papp 2.12) makes TRIZAC a promising ligand for studying 5-HT-3 receptors.