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2-bromoethyl glycosides in glycoside synthesis: Preparation of glycoproteins containing α-l-Fuc-(1→2)-d-Gal and β-d-Gal-(1→4)-d-GlcNAc

✍ Scribed by Jan Dahmén; Torbjörn Frejd; Göran Magnusson; Ghazi Noori; Anne-Sofie Carlström

Publisher: Elsevier Science
Year: 1984
Tongue: English
Weight: 808 KB
Volume: 125
Category: Article
ISSN: 0008-6215
DOI: 10.1016/0008-6215(84)85159-9

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✦ Synopsis

The applicability of 2-bromoethyl glycosides in carbohydrate synthesis is demonstrated by the synthesis of glycosides of a-L-Fuc-(1+2)-D-Gal and /?-D-Gal-(1+4)-D-GlcNAc. The bromoethyl aglycon was transformed into the methoxycarbonylethylthioethyl spacer, which allowed coupling of the sugars to proteins (BSA and KLH) .

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