2-Bromoethyl glycosides: applications in the synthesis of spacer-arm glycosides
✍ Scribed by Jan Dahmén; Torbjörn Frejd; Gunnar Grönberg; Thomas Lave; Göran Magnusson; Ghazi Noori
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- English
- Weight
- 746 KB
- Volume
- 118
- Category
- Article
- ISSN
- 0008-6215
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Progress in the chemistry of glycoconjugates during the last decade reflects the availability of a wide array of methods for stereoselective 0-glycosylation'-3. Carbohydrate segments of biological interest can be coupled through a spacer4 to a soluble protein to yield synthetic antigens, and attachm
The applicability of 2-bromoethyl glycosides in carbohydrate synthesis is demonstrated by the synthesis of glycosides of a-L-Fuc-(1+2)-D-Gal and /?-D-Gal-(1+4)-D-GlcNAc. The bromoethyl aglycon was transformed into the methoxycarbonylethylthioethyl spacer, which allowed coupling of the sugars to prot