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2-Bromo-1-arylethylidenemalononitriles — Convenient reagents for the regioselective synthesis of fused pyridines

✍ Scribed by Vasilii A. Artyomov; Vladimir L. Ivanov; Anatolii M. Shestopalov; Victor P. Litvinov

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
388 KB
Volume
53
Category
Article
ISSN
0040-4020

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✦ Synopsis

2-Bromo-l-arylethylidenemalononitriles react with conjugated thiolatonitriles to give products of regioselective S alkylation that can be subsequently involved in the Thorpe reaction Resulting enaminoaerylonitriles form pyridine ring under base catalysis yielding thienodipyridines. According to this common scheme, fimctionally substituted thieno[3,2-b]pyridines, thiazolo[4,5b]pyridines, thieno[3,2-b:4,5-h "]dipyridines, their hydrogenated analogues, and pyrido[2',3':4,5]thieno[2,3-d]pyrimidine were synthesized

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