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2-Aminothiazole based P2Y1 antagonists as novel antiplatelet agents

โœ Scribed by Pi, Zulan; Sutton, James; Lloyd, John; Hua, Ji; Price, Laura; Wu, Qimin; Chang, Ming; Zheng, Joanna; Rehfuss, Robert; Huang, Christine S.; Wexler, Ruth R.; Lam, Patrick Y.S.


Book ID
120971021
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
1020 KB
Volume
23
Category
Article
ISSN
0960-894X

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Benzofuran-substituted urea derivatives
โœ Reema K. Thalji; Nambi Aiyar; Elizabeth A. Davenport; Joseph A. Erhardt; Lorena ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 249 KB

Benzofuran-substituted urea analogs have been identified as novel P2Y(1) receptor antagonists. Structure-activity relationship studies around the urea and the benzofuran moieties resulted in compounds having improved potency. Several analogs were shown to inhibit ADP-mediated platelet activation.