2-Amino- N -pyrimidin-4-ylacetamides as A 2A Receptor Antagonists: 1. Structure−Activity Relationships and Optimization of Heterocyclic Substituents
✍ Scribed by Slee, Deborah H.; Chen, Yongsheng; Zhang, Xiaohu; Moorjani, Manisha; Lanier, Marion C.; Lin, Emily; Rueter, Jaimie K.; Williams, John P.; Lechner, Sandra M.; Markison, Stacy; Malany, Siobhan; Santos, Mark; Gross, Raymond S.; Jalali, Kayvon; Sai, Yang; Zuo, Zhiyang; Yang, Chun; Castro-Palomino, Julio C.; Crespo, María I.; Prat, Maria; Gual, Silvia; Díaz, José-Luis; Saunders, John
- Book ID
- 118183694
- Publisher
- American Chemical Society
- Year
- 2008
- Tongue
- English
- Weight
- 201 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0022-2623
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
The synthesis and SAR studies of thieno [2,3-d]pyrimidine-2,4-diones as human GnRH receptor antagonists to treat reproductive diseases are discussed. It was found that the 2-(2-pyridyl)ethyl group on the 5-aminomethyl functionality of the core structure was a key feature for good receptor binding ac