✦ LIBER ✦

2-Amino diphenylsulfides as inhibitors of trypanothione reductase: modification of the side chain

✍ Scribed by Stéphanie Baillet; Eric Buisine; Dragos Horvath; Louis Maes; Beatrice Bonnet; Christian Sergheraert

Book ID: 103992303
Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 869 KB
Volume: 4
Category: Article
ISSN: 0968-0896
DOI: 10.1016/0968-0896(96)00083-1

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

2-Amino diphenylsulfides as new inhibito

2-Amino diphenylsulfides as new inhibitors of trypanothione reductase

✍ Rodolfo Fernandez-Gomez; Mireille Moutiez; Marc Aumercier; Gilles Bethegnies; Mi 📂 Article 📅 1995 🏛 Elsevier Science 🌐 English ⚖ 794 KB

Discovery of 2-iminobenzimidazoles as a

Discovery of 2-iminobenzimidazoles as a new class of trypanothione reductase inhibitor by high-throughput screening

✍ Georgina A. Holloway; Jonathan B. Baell; Alan H. Fairlamb; Patrizia M. Novello; 📂 Article 📅 2007 🏛 Elsevier Science 🌐 English ⚖ 202 KB

ChemInform Abstract: New Potent Inhibito

ChemInform Abstract: New Potent Inhibitors of Trypanothione Reductase from Trypanosoma cruzi in the 2-Aminodiphenylsulfide Series.

✍ S. GIRAULT; S. BAILLET; D. HORVATH; V. LUCAS; E. DAVIOUD-CHARVET; A. TARTAR; C. 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 28 KB 👁 2 views

New Potent Inhibitors of Trypanothione Reductase from Trypanosoma cruzi in the 2-Aminodiphenylsulfide Series. -A series of compounds such as (I)-(III) are prepared to investigate their TR inhibition. Derivative (Ib) is revealed to be the best inhibitor described so far.

ChemInform Abstract: Metal-Mediated Modi

ChemInform Abstract: Metal-Mediated Modification of the Side-Chains of α-Amino Acids

✍ Geoffrey T. Crisp 📂 Article 📅 2000 🏛 John Wiley and Sons ⚖ 26 KB 👁 1 views

Synthesis of 5,5′-Dithiobis(2-nitrobenza

Synthesis of 5,5′-Dithiobis(2-nitrobenzamides)as Alternative Substrates for Trypanothione Reductase and Thioredoxin Reductase: A Microtiter Colorimetric Assay for Inhibitor Screening

✍ Elisabeth Davioud-Charvet; Katja Becker; Valérie Landry; Stephan Gromer; Cédric 📂 Article 📅 1999 🏛 Elsevier Science 🌐 English ⚖ 87 KB

Synthesis and Evaluation of 1-(1-(Benzo[

Synthesis and Evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) Analogues as Inhibitors of Trypanothione Reductase

✍ Stephen Patterson; Deuan C. Jones; Emma J. Shanks; Julie A. Frearson; Ian H. Gil 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 403 KB 👁 1 views

## Abstract __Thirty two analogues of phencyclidine were synthesised and tested as inhibitors of trypanothione reductase (TryR), a potential drug target in trypanosome and leishmania parasites. The lead compound BTCP (**1**, 1‐(1‐benzo[__b__]thiophen‐2‐yl‐cyclohexyl) piperidine) was found to be a c