2-Amino-4-(2,5-dichlorophenyl)-5-(1H-1,2,4-triazol-1-yl)-1,3-thiazole
✍ Scribed by Shao, Ling ;Jin, Zhong ;Liu, Jian-Bing ;Zhou, Xin ;Zhang, Qing ;Hu, Yan ;Fang, Jian-Xin
- Publisher
- International Union of Crystallography
- Year
- 2004
- Tongue
- English
- Weight
- 313 KB
- Volume
- 60
- Category
- Article
- ISSN
- 1600-5368
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✦ Synopsis
Single-crystal X-ray study T = 293 K Mean '(C±C) = 0.003 A Ê R factor = 0.026 wR factor = 0.062 Data-to-parameter ratio = 12.9
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The structure of the title compound, C 22 H 15 ClN 2 O 4 S, comprises non-planar molecules that form a one-dimensional hydrogen-bonded chain via a single N-HÁ Á ÁO interaction, which runs parallel to the b axis. The dihedral angle between the thiazole and quinone rings is 50.43 ( 7) and the dihedral
The title compound, C 17 H 12 ClN 5 S, has been synthesized as a potent anticancer agent. The dihedral angle between the thiazole and triazole rings is 85.9 (2) . There are intermolecular N-HÁ Á ÁN and C-HÁ Á ÁCl interactions in the crystal structure.
The title compound, C 20 H 14 N 12 S 2 , was synthesized by the reaction of 3-hydrazino-1H-1,2,4-triazole with phenyl isocyanate in benzene and by ring closure in an alkaline medium. Intermolecular N-HÁ Á ÁN hydrogen bonds are observed and these form a five-membered ring.