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2-Amino-3-(methylamino)propanoic acid (BMAA) bioavailability in the primate

โœ Scribed by Duncan, Mark W.; Markey, Sanford P.; Weick, Barton G.; Pearson, Philip G.; Ziffer, Herman; Hu, Yulin; Kopin, Irwin J.


Book ID
122617686
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
475 KB
Volume
13
Category
Article
ISSN
0197-4580

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Synthesis and optical resolution of the
โœ Yulin Hu; Herman Ziffer ๐Ÿ“‚ Article ๐Ÿ“… 1990 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 208 KB

## Abstract The synthesis of 2โ€aminoโ€3โ€([^15^N]โ€methylamino)propanoic acid (synonyms, BMAA, ฮฒโ€Nโ€methylaminoโ€alanine) from ฮฑโ€acetamidoacrylic acid and [^15^N]โ€methylamine is described. Enantioselective hydrolysis of the acetamide group, mediated by the enzyme Acylase 1 (EC 3.5.1.14), yielded (R)โ€BMA