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2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) induces genetic changes in murine intestinal tumours and cells with ApcMin mutation

✍ Scribed by Å. Andreassen; R. Vikse; A. Mikalsen; T. Adamovic; I.-L. Steffensen; H. Hjertholm; G. Levan; J. Alexander

Book ID: 116759091
Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 283 KB
Volume: 604
Category: Article
ISSN: 1383-5718
DOI: 10.1016/j.mrgentox.2006.01.004

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## Abstract 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐__b__]pyridine (PhIP) is the most abundant heterocyclic amine derived from food, possibly involved in human carcinogenesis. We evaluated the formation of PhIP‐DNA adducts in lymphocytes from 76 incident colorectal cancer patients likely to be exposed