2-Alkyl-4-arylimidazoles: Structurally Novel Sodium Channel Modulators.
โ Scribed by Anne-Marie Liberatore; Jocelyne Schulz; Jacques Pommier; Marie-Anne Barthelemy; Marion Huchet; Pierre-Etienne Chabrier; Dennis Bigg
- Book ID
- 101968140
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 20 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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โฆ Synopsis
Abstract
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๐ SIMILAR VOLUMES
The interactions of a family of aminopyridine derivatives with Site II of the voltage-dependent sodium channel were examined by measuring the ability of these compounds to inhibit [ 3 H]batrachotoxin binding and veratridine-induced increases in [Ca 2+ ] i . Aminopyridines substituted with indole, ca
We report here a convenient and efficient two-step synthesis of 1-aryl-2-arylamino-4-alkyl/phenyl-5aroyl-1H-imidazoles from easily available amidinothioureas. Guanylation of amidinothioureas 1 using mercury(II) chloride as a thiophile yielded amidinoguanidines 2, which reacted with various phenacyl