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2-Acetylaminofluorene metabolism in rat liver microsomes: Formation of 9-hydroxy-2-acetylaminofluorene and effect of hepatic enzyme modifiers

✍ Scribed by Ock Soon Son; John W. Fowble; Duane D. Miller; Dennis R. Feller


Book ID
116072610
Publisher
Elsevier Science
Year
1979
Tongue
English
Weight
881 KB
Volume
51
Category
Article
ISSN
0041-008X

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Monolayers of rat hepatocytes metabolize 0.25 mM 2acetylaminofluorene (AA F) to various ether-extractable, watersoluble as well as covalently bound products. The major ether-extractable metabolite formed is 2-aminofluorene (AF), followed by 7-OH-AAF and 9-OH-AAF. Pretreatment of rats with the induce