Direct synthesis of δ-lactones from 2-(3
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Diego J. Ramón; Miguel Yus
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Article
📅
1990
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Elsevier Science
🌐
French
⚖ 239 KB
The reaction of 2-(3-lithiopropyl)-1,3-dioxolane (2). prepared in situ by lithiation of the chloroacetal 1 with lithium naphthalenide at -7X"C, with aldehydes and ketones followed by hydrolysis with hydrochloric acid and final oxidation with PCC or Jones reagent yields the corresponding&lactones 5.