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2-(3-Lithiopropyl)- and 2-(3-lithiopropyl)-2-methyl-1,3-dioxolane: New masked lithium bishomoenolates in the synthesis of bifunctionalized compounds

✍ Scribed by Diego J. Ramón; Miguel Yus


Publisher
Elsevier Science
Year
1990
Tongue
French
Weight
255 KB
Volume
31
Category
Article
ISSN
0040-4039

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Direct synthesis of δ-lactones from 2-(3
✍ Diego J. Ramón; Miguel Yus 📂 Article 📅 1990 🏛 Elsevier Science 🌐 French ⚖ 239 KB

The reaction of 2-(3-lithiopropyl)-1,3-dioxolane (2). prepared in situ by lithiation of the chloroacetal 1 with lithium naphthalenide at -7X"C, with aldehydes and ketones followed by hydrolysis with hydrochloric acid and final oxidation with PCC or Jones reagent yields the corresponding&lactones 5.